CMS121 powder olupese CAS No.: 1353224-53-9 98.0% mimo min. fun awọn eroja afikun
Ọja paramita
| Orukọ ọja | CMS121 |
| Oruko miiran | CMS-121; 1,2-Benzenediol, 4- [4- (cyclopentyloxy) -2-quinolinyl] -; 4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol (CMS121); ACC, AcetylCoenzymeACarboxylase, arun, neuroprotective, dojuti, egboogi-iredodo, mitochondrial, Alzheimer's, antioxidative, acetylation, inhibitor, H3K9, Acetyl-CoACarboxylase, CMS121, iyawere, ACC1, CMS-121 |
| CAS No. | 1353224-53-9 |
| Ilana molikula | C20H19NO3 |
| Ìwúwo molikula | 321.37 |
| Mimo | 98.0% |
| Ifarahan | Ina ofeefee lulú |
| Ohun elo | Ounjẹ Iyọnda Aise Ohun elo |
ifihan ọja
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol jẹ apopọ ti a npe ni CMS121. Idiju igbekalẹ agbo naa daba pe o le ni awọn ohun-ini alailẹgbẹ ati awọn lilo agbara. Lati loye pataki rẹ, o ṣe iranlọwọ lati ṣe idanimọ awọn ẹgbẹ iṣẹ ṣiṣe ti o wa ati ṣe itupalẹ ipa agbara wọn. Iwaju iwọn quinoline ni imọran pe agbo-ara le ṣiṣẹ ni biologically. Awọn ohun alumọni ti Quinoline ni a mọ fun oniruuru awọn ohun-ini ibi-aye wọn, pẹlu awọn iṣẹ antibacterial ati egboogi-iredodo. Asomọ ti ẹgbẹ cyclopentyloxy le ṣe alabapin si solubility ti yellow tabi mu iṣẹ ṣiṣe ti ibi rẹ pọ si nipasẹ awọn ipa sitẹriiki. Ninu awọn ẹkọ lori awọn sẹẹli HT22, CMS-121 ti ṣe afihan awọn ipa neuroprotective pataki, aabo aabo awọn sẹẹli wọnyi ni imunadoko lati ischemia ati ibajẹ oxidative. Pẹlupẹlu, CMS-121 ni awọn ohun-ini egboogi-egbogi pataki, ti o nfihan agbara rẹ lati ṣe atunṣe awọn idahun iredodo. Nipa ṣiṣe bẹ, CMS-121 ni agbara lati dinku igbona ni orisirisi awọn ara ati awọn ara. CMS-121 ni iṣẹ elegbogi ti o lagbara bi oludena ti acetyl-CoA carboxylase 1 (ACC1). Awọn oniwe-agbara inhibitory ipa lori ACC1 mu ki o kan ni ileri yellow.
Ẹya ara ẹrọ
(1) Iwa mimọ giga: CMS-121 le gba awọn ọja mimọ-giga nipasẹ awọn ilana iṣelọpọ isọdọtun. Mimo giga tumọ si bioavailability to dara julọ ati awọn aati ikolu ti o dinku.
(2) Aabo: Aabo giga, awọn aati ikolu diẹ.
(3) Iduroṣinṣin: CMS-121 ni iduroṣinṣin to dara ati pe o le ṣetọju iṣẹ rẹ ati ipa labẹ awọn agbegbe oriṣiriṣi ati awọn ipo ipamọ.
Awọn ohun elo
CMS-121 jẹ itọsẹ quinolone kan ati ẹnu ti nṣiṣe lọwọ acetyl-CoA carboxylase 1 (ACC1) inhibitor pẹlu awọn ohun-ini elegbogi ti o ni ileri. Iwadi nla ni a ti ṣe lati ṣe iwadii awọn anfani ti o pọju ti CMS-121 ni awọn agbegbe pupọ, pẹlu neuroprotection, awọn ipa-egbogi-iredodo, iṣẹ-ṣiṣe antioxidant, ati ipa rẹ lori awọn ami-ami ti o ni nkan ṣe pẹlu arugbo ilera.
